| PHARMACOLOGY |
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| Year : 2009 | Volume
: 1
| Issue : 1 | Page : 57-62 |
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Protective effect of polyherbal formulation on simvastatin hepatotoxicity in rats
J Vaghasiya, S Rathod, Y Bhalodia, R Manek, S Malaviya, N Jivani
Smt. R.B. Patel Mahila Pharmacy College, S.N.D.T Women's University, Atkot, Gujarat, India
Correspondence Address:
J Vaghasiya
Smt. R.B. Patel Mahila Pharmacy College, S.N.D.T Women's University, Atkot, Gujarat
India
DOI: 10.4103/0975-1483.51883
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Objective: This study was designed to assess the effect of polyherbal formulation (PHF) on simvastatin hepatotoxicity in rats and to assess the possibility of co-administration of PHF along with hepatotoxic drugs. Methods: Hepatotoxicity in rats was induced by simvastatin (20 mg/kg p.o. for 30 days) and the protective effect of PHF (0.25 ml/kg/p.o. and 0.5 ml/kg/p.o. either along with drug or followed by inducing hepatotoxicity) was identified by estimating marker enzymes for liver function such as aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and g glutamic transpeptidase; oxidative stress markers such as lipid peroxidation, reduced glutathione, super oxide dismutase, and catalase; and protein profile such as total bilirubin, direct bilirubin, total albumin, and total protein. A histopathological study was also carried out to confirm hepatotoxicity. Results and Discussions: Simvastatin hepatotoxicity was characterized by a significant increase in oxidative stress along with marker enzymes of liver function and depletion of proteins. Administration of PHF either along with simvastatin or followed by inducing hepatotoxicity significantly improved the level of marker enzymes for liver function, oxidative stress, and protein profile. Conclusion: The study suggests a protective role of PHF on simvastatin hepatotoxicity and it can be utilized to treat hepatotoxicity with long-term clinically useful drugs. |
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